ARA-290

ARA-290

What is ARA-290

Advanced Peptide for Inflammation, Nerve Repair, and Metabolic Support

ARA-290, also known as Cibinetide, is a synthetic peptide derived from erythropoietin (EPO) that selectively targets the innate repair receptor (IRR) — a pathway responsible for tissue protection and anti-inflammatory signaling without stimulating red blood cell production.

Neurological and Nerve Effects

• Promotes nerve repair and regeneration — especially in small-fiber neuropathy and diabetic neuropathy

• Reduces neuropathic pain by decreasing inflammation and improving small nerve fiber density

• Improves autonomic function, including heart rate variability and sweat gland function (in some studies)

Anti-Inflammatory Effects

• Suppresses pro-inflammatory cytokines (such as TNF-α and IL-6)

• Restores immune balance by modulating macrophage and microglial activation

• Protects tissues from inflammatory damage in autoimmune and metabolic conditions

Metabolic and Mitochondrial Effects

• Enhances insulin sensitivity and glucose uptake

• Improves mitochondrial function and energy efficiency at the cellular level

• Reduces oxidative stress, supporting overall metabolic health

Tissue Protection and Recovery

• Protects organs (kidneys, heart, and muscles) from ischemic or toxic injury

• Accelerates recovery from tissue damage and promotes cellular resilience

• Supports vascular health by improving endothelial function